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TPP1 Rabbit mAb

     
  • 1 - TPP1 Rabbit mAb AP76190
    Western blot analysis of TPP1 in Hela, Jurkat, HepG2 lysates using TPP1 antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P
Primary Accession O14773
Reactivity Rat, Human, Mouse
Host Rabbit
Clonality Monoclonal Antibody
Isotype IgG
Conjugate Unconjugated
Purification Affinity Purified
Calculated MW 61248 Da
Additional Information
Gene ID 1200
Other Names TPP1
Dilution WB~~1:1000-1:5000
IHC-P~~1:50~200
Format Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name TPP1
Synonyms CLN2
Function Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967). Requires substrates with an unsubstituted N-terminus (PubMed:19038966).
Cellular Location Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Tissue Location Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues
Research Areas

BACKGROUND

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus .

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