癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRIM23/ARD1 Rabbit mAb
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Application 
| WB |
|---|---|
| Primary Accession | P36406 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Affinity Purified |
| Calculated MW | 64067 Da |
| Gene ID | 373 |
|---|---|
| Other Names | TRIM23 |
| Dilution | WB~~1:2000-1:5000 |
| Format | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TRIM23 |
|---|---|
| Synonyms | ARD1, ARFD1, RNF46 |
| Function | E3 ubiquitin ligase that harbors GTPase activity encoded by the C-terminal ARF domain. Plays an essential role in autophagy activation during viral infection (PubMed:31189704, PubMed:40360474). Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1 (PubMed:28871090, PubMed:31189704). In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). Catalyzes 'Lys-63'-linked polyubiquitination of HAX1 that triggers its liquid- liquid phase separation (LLPS) and contributes to P-bodies assembly induced by energy stress (PubMed:38769438). |
| Cellular Location | Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Cytoplasm, P-body. Note=Membrane-associated with the Golgi complex and lysosomal structures |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
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