癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FKBP6 Rabbit mAb
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O75344 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Affinity Purified |
| Calculated MW | 37214 Da |
| Gene ID | 8468 |
|---|---|
| Other Names | FKBP6 |
| Dilution | WB~~1:1000 IHC-P~~1:50~200 |
| Format | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FKBP6 |
|---|---|
| Synonyms | FKBP36 |
| Function | Has an essential role in spermatogenesis (PubMed:36150389). It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co- chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping- pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=In spermatocytes, it colocalizes with PIWIL1 in large cytoplasmic granules (PubMed:36150389). Does not localize to the synaptonemal complex (PubMed:36150389) |
| Tissue Location | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6), also known as 36 kDa FK506-binding protein (36 kDa FKBP; FKBP-36), is a member of a gene family that contains a prolyl isomerase/FK506 binding domain and tetratricopeptide protein-protein interaction domains(PMID: 9782077). It has been linked to the secondary piRNA biogenesis in fetal male mouse germ cells ( PMID: 22902560).
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