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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   Phospholipase C gamma 1 Rabbit mAb   

Phospholipase C gamma 1 Rabbit mAb

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP, ICC
Primary Accession P19174
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal Antibody
Calculated MW 148532 Da
Additional Information
Gene ID 5335
Other Names PLCG1
Dilution WB~~1/500-1/1000
IP~~N/A
ICC~~N/A
Format Liquid
Protein Information
Name PLCG1 (HGNC:9065)
Synonyms PLC1
Function Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity).
Cellular Location Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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