PDK1 Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IP |
---|---|
Primary Accession | Q15118 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 49244 Da |
Gene ID | 5163 |
---|---|
Other Names | PDK1 |
Dilution | WB~~1/500-1/1000 IP~~N/A |
Format | Liquid |
Name | PDK1 |
---|---|
Synonyms | PDHK1 |
Function | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). |
Cellular Location | Mitochondrion matrix |
Tissue Location | Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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