癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ATF2 Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IF, ICC, IP |
|---|---|
| Primary Accession | P15336 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Immunogen | A synthesized peptide derived from human ATF2 |
| Purification | Affinity Chromatography |
| Calculated MW | 54537 Da |
| Gene ID | 1386 |
|---|---|
| Other Names | ATF2 |
| Dilution | WB~~1/500-1/1000 IHC-P~~1:50~200 IF~~1:50~200 ICC~~N/A IP~~N/A |
| Format | Liquid in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATF2 |
|---|---|
| Synonyms | CREB2, CREBP1 |
| Function | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response (PubMed:11932306, PubMed:15105425, PubMed:15916964, PubMed:22304920, PubMed:2529117). Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (PubMed:11932306, PubMed:2529117). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death (PubMed:22304920). In liver, acts as a regulator of glucose metabolism downstream of OR5V1 signaling, which promotes ATF2 activation, leading to expression of carnitine palmitoyltransferase CPT1A (By similarity). In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death (PubMed:22304920). The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF) (PubMed:15916964). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (PubMed:18397884). Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (PubMed:18677098). |
| Cellular Location | Nucleus. Cytoplasm Mitochondrion outer membrane Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization (PubMed:22275354). Localization to the cytoplasm is observed under conditions of cellular stress and in disease states (PubMed:22304920) Localizes at the mitochondrial outer membrane in response to genotoxic stress (PubMed:22304920). Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization (PubMed:22304920). Co-localizes with the MRN complex in the IR-induced foci (IRIF) (PubMed:15916964) |
| Tissue Location | Ubiquitously expressed, with more abundant expression in the brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP77386
