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>   首页   >   产品   >   一抗   >   心血管   >   CTGF Antibody (C-term)   

CTGF Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CTGF Antibody (C-term) AP7778B
    Western blot analysis of CTGF Antibody (C-term) (Cat. #AP7778b) in NCI-H460 cell line lysates (35ug/lane). CTGF (arrow) was detected using the purified Pab.
  • 14 - CTGF Antibody (C-term) AP7778B
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CTGF antibody (C-term) (Cat.#AP7778b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession P29279
Other Accession Q9R1E9, O19113, P29268, O18739, NP_001892
Reactivity Human, Rat, Mouse
Predicted Bovine, Mouse, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38091 Da
Antigen Region 315-349 aa
Additional Information
Gene ID 1490
Other Names Connective tissue growth factor, CCN family member 2, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8, CTGF, CCN2, HCS24, IGFBP8
Target/Specificity This CTGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-349 amino acids from the C-terminal region of human CTGF.
Dilution IHC-P~~1:100~500
WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTGF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCN2 (HGNC:2500)
Function Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor- induced DNA synthesis.
Cellular Location Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P29268}. Secreted
Tissue Location Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Connective tissue growth factor (CTGF), a member of the CCN family of secreted matricellular proteins, regulates fibrosis, angiogenesis, cell proliferation, apoptosis, tumor growth, and metastasis.

REFERENCES

Li,M.H., Mol. Cancer Res. 6 (10), 1649-1656 (2008)
Bogatkevich,G.S., Am. J. Physiol. Lung Cell Mol. Physiol. 295 (4), L603-L611 (2008)
Zhang,P., Tohoku J. Exp. Med. 215 (3), 199-206 (2008)

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