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>   首页   >   产品   >   一抗   >   信号转导   >   Activin Receptor Type IA (ACVR1) Antibody (Center R147)   

Activin Receptor Type IA (ACVR1) Antibody (Center R147)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Activin Receptor Type IA (ACVR1) Antibody (Center R147) AP7806C
    Western blot analysis of lysate from HepG2 cell line, using ACVR1 Antibody (R147)(Cat. # AP7806c). AP7806c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
  • 1 - Activin Receptor Type IA (ACVR1) Antibody (Center R147) AP7806C
    Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (R147) (Cat.#AP7806c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1 gene.
  • 1 - Activin Receptor Type IA (ACVR1) Antibody (Center R147) AP7806C
    ACVR1 Antibody (R147) (Cat. #AP7806c) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the ACVR1 antibody detected the ACVR1 protein (arrow).
  • 14 - Activin Receptor Type IA (ACVR1) Antibody (Center R147) AP7806C
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q04771
Other Accession P80201, P37172, Q28041
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57153 Da
Additional Information
Gene ID 90
Other Names Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2
Target/Specificity This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the Central region of human Activin Receptor Type IA (ACVR1).
Dilution WB~~1:1000
IHC-P~~1:100~500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsActivin Receptor Type IA (ACVR1) Antibody (Center R147) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACVR1
Synonyms ACVRLK2
Function Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:20628059, PubMed:22977237). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401). Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain (PubMed:25354296). In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal (PubMed:9748228). In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (PubMed:17911401). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells
Research Areas

BACKGROUND

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors.

REFERENCES

Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002).
Roijer, E., et al., Mamm. Genome 9(3):266-268 (1998).
Attisano, L., et al., Cell 75(4):671-680 (1993).
ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).
Matsuzaki, K., et al., J. Biol. Chem. 268(17):12719-12723 (1993).

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