MUC20 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, IF, E |
---|---|
Primary Accession | Q8N307 |
Other Accession | Q86ST8 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 71982 Da |
Antigen Region | 61-90 aa |
Gene ID | 200958 |
---|---|
Other Names | Mucin-20, MUC-20, MUC20, KIAA1359 |
Target/Specificity | This MUC20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human MUC20. |
Dilution | WB~~1:2000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MUC20 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MUC20 |
---|---|
Synonyms | KIAA1359 |
Function | May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. |
Cellular Location | Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane |
Tissue Location | Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules Detected in most of the male urogenital tract epithelia, with the exception of epididymis. |
For Research Use Only. Not For Use In Diagnostic Procedures.

Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in different individuals. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Li,G., Am. J. Nephrol. 26 (1), 43-49 (2006)
Suzuki,Y., Genome Res. 14 (9), 1711-1718 (2004)
Higuchi,T., Mol. Cell. Biol. 24 (17), 7456-7468 (2004)
Higuchi,T., J. Biol. Chem. 279 (3), 1968-1979 (2004)

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