癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ALDH1A3 Antibody (N-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 15
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P47895 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56108 Da |
| Antigen Region | 24-52 aa |
| Gene ID | 220 |
|---|---|
| Other Names | Aldehyde dehydrogenase family 1 member A3, Aldehyde dehydrogenase 6, Retinaldehyde dehydrogenase 3, RALDH-3, RalDH3, ALDH1A3, ALDH6 |
| Target/Specificity | This ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ALDH1A3. |
| Dilution | WB~~1:2000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALDH1A3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ALDH1A3 |
|---|---|
| Synonyms | ALDH6 {ECO:0000303|PubMed:7698756} |
| Function | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9JHW9}. |
| Tissue Location | Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
REFERENCES
Rexer,B.N., Cancer Res. 61 (19), 7065-7070 (2001)
Yoshida,A., Eur. J. Biochem. 251 (3), 549-557 (1998)
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