癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PI3KR5 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WYR1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 97348 Da |
| Antigen Region | 392-421 aa |
| Gene ID | 23533 |
|---|---|
| Other Names | Phosphoinositide 3-kinase regulatory subunit 5, PI3-kinase regulatory subunit 5, PI3-kinase p101 subunit, Phosphatidylinositol 4, 5-bisphosphate 3-kinase regulatory subunit, PtdIns-3-kinase regulatory subunit, Protein FOAP-2, PtdIns-3-kinase p101, p101-PI3K, PIK3R5 |
| Target/Specificity | This PI3KR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-421 amino acids from the Central region of human PI3KR5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PI3KR5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIK3R5 |
|---|---|
| Function | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein- mediated activation of PIK3CG (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O02696}. Cytoplasm {ECO:0000250|UniProtKB:O02696}. Cell membrane {ECO:0000250|UniProtKB:O02696}; Peripheral membrane protein {ECO:0000250|UniProtKB:O02696}. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250|UniProtKB:O02696} |
| Tissue Location | Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PI3KR5 is a regulatory subunit of the PI3K gamma complex. This protein, which interacts with G beta gamma proteins, is a heterodimer of a catalytic subunit (PI3KCG/p120) and a regulatory (PI3KR5a/p101) subunit.
REFERENCES
Brock, C., et al., J. Cell Biol. 160(1):89-99 (2003).
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