NME7 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| IHC-P, WB, E |
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Primary Accession | Q9Y5B8 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42492 Da |
Antigen Region | 25-55 aa |
Gene ID | 29922 |
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Other Names | Nucleoside diphosphate kinase 7, NDK 7, NDP kinase 7, nm23-H7, NME7 |
Target/Specificity | This NME7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human NME7. |
Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NME7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NME7 (HGNC:20461) |
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Function | Possesses an intrinsic kinase activity (PubMed:24807905). Displays 3'-5' exonuclease activity with a preference for single- stranded DNA (PubMed:16313181). Does not seem to have nucleoside diphosphate kinase activity (PubMed:16313181, PubMed:24807905). Functional component of the gamma-tubulin ring complex, implicated in the regulation of the microtubule-nucleating activity of the gamma- tubulin ring complex in centrosomes, in a kinase activity-dependent manner (PubMed:24807905). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5E9Y9}. Cell projection, cilium. Note=Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1. |
Tissue Location | Expressed in airway epithelial cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
REFERENCES
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).

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