癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BAIAP1 (MAGI1)Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96QZ7 |
| Other Accession | Q4L1J4, NP_004733 |
| Reactivity | Human |
| Predicted | Rat, Mouse, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 164581 Da |
| Antigen Region | 1227-1256 aa |
| Gene ID | 9223 |
|---|---|
| Other Names | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, Atrophin-1-interacting protein 3, AIP-3, BAI1-associated protein 1, BAP-1, Membrane-associated guanylate kinase inverted 1, MAGI-1, Trinucleotide repeat-containing gene 19 protein, WW domain-containing protein 3, WWP3, MAGI1, AIP3, BAIAP1, BAP1, TNRC19 |
| Target/Specificity | This BAIAP1 (MAGI1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1227-1256 amino acids from the C-terminal region of human BAIAP1 (MAGI1). |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BAIAP1 (MAGI1)Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAGI1 |
|---|---|
| Synonyms | AIP3, BAIAP1, BAP1, TNRC19 |
| Function | Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). |
| Cellular Location | Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions |
| Tissue Location | Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
BAIAP1 is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. Characterized by two WW domains, a guanylate kinase domain, and five PDZ domains, this protein interacts with the cytoplasmic region of BAI1. Together, these proteins may play a role in cell adhesion and signal transduction.
REFERENCES
Patrie, K.M., et al., J. Biol. Chem. 277(33):30183-30190 (2002).
Shiratsuchi, T., et al., Biochem. Biophys. Res. Commun. 247(3):597-604 (1998).
Wood, J.D., et al., Mol. Cell. Neurosci. 11(3):149-160 (1998).
Margolis, R.L., et al., Hum. Genet. 100(1):114-122 (1997).
Pirozzi, G., et al., J. Biol. Chem. 272(23):14611-14616 (1997).
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