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Choline kinase alpha (CHK) Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P35790 |
| Other Accession | NP_001268 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52249 Da |
| Antigen Region | 427-457 aa |
| Gene ID | 1119 |
|---|---|
| Other Names | Choline kinase alpha, CK, CHETK-alpha, Ethanolamine kinase, EK, CHKA, CHK, CKI |
| Target/Specificity | This Choline kinase alpha (CHK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 427-457 amino acids from the C-terminal region of human Choline kinase alpha (CHK). |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Choline kinase alpha (CHK) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CHKA |
|---|---|
| Synonyms | CHK, CKI {ECO:0000303|PubMed:1618328} |
| Function | Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis (PubMed:17007874, PubMed:19915674, PubMed:23416529, PubMed:34077757). Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis (PubMed:17007874, PubMed:19915674). Has higher activity with choline (PubMed:17007874, PubMed:19915674). May contribute to tumor cell growth (PubMed:19915674). |
| Cellular Location | Cytoplasm, cytosol. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase alpha is the initial enzyme in the sequence and may play a regulatory role. This protein also catalyzes the phosphorylation of ethanolamine. The antibody for this protein recognizes both isoforms.
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