癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTP gamma Antibody (Center) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P23470 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 162003 Da |
| Antigen Region | 751-782 aa |
| Gene ID | 5793 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase gamma, Protein-tyrosine phosphatase gamma, R-PTP-gamma, PTPRG, PTPG |
| Target/Specificity | This PTP gamma antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-782 amino acids from the Central region of human PTP gamma. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTP gamma Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTPRG |
|---|---|
| Synonyms | PTPG |
| Function | Possesses tyrosine phosphatase activity. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Found in a variety of tissues. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PTPgamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. The gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
REFERENCES
Liu, S., et al., Breast Cancer Res. Treat. 71(1):21-35 (2002).
Kastury, K., et al., Genomics 32(2):225-235 (1996).
Barnea, G., et al., Mol. Cell. Biol. 13(3):1497-1506 (1993).
LaForgia, S., et al., Proc. Natl. Acad. Sci. U.S.A. 88(11):5036-5040 (1991).
Krueger, N.X., et al., EMBO J. 9(10):3241-3252 (1990).
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