|Application ||IHC-P, FC, WB, E|
|Other Accession||P97360, Q0VC65|
|Calculated MW||53000 Da|
|Other Names||Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1|
|Target/Specificity||This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the N-terminal region of human ETV6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ETV6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.|
Provided below are standard protocols that you may find useful for product applications.
ETV6 is an ETS family transcription factor. This protein contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain.
Buijs,A., et.al., Oncogene 10 (8), 1511-1519 (1995)
Golub,T.R.,et.al., Proc. Natl. Acad. Sci. U.S.A. 92 (11), 4917-4921 (1995)