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>   首页   >   产品   >   一抗   >   细胞生物学   >   DPP10 Antibody (Center)   

DPP10 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DPP10 Antibody (Center) AP9000c
    Western blot analysis of DPP10 Antibody (Center) (Cat. #AP9000c) in Y79, MDA-MB231 cell line and mouse liver, brain tissue lysates (35ug/lane). DPP10 (arrow) was detected using the purified Pab.
  • 14 - DPP10 Antibody (Center) AP9000c
    DPP10 Antibody (Center) (Cat. #AP9000c) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DPP10 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8N608
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 90888 Da
Antigen Region 150-177 aa
Additional Information
Gene ID 57628
Other Names Inactive dipeptidyl peptidase 10, Dipeptidyl peptidase IV-related protein 3, DPRP-3, Dipeptidyl peptidase X, DPP X, Dipeptidyl peptidase-like protein 2, DPL2, DPP10, DPRP3, KIAA1492
Target/Specificity This DPP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-177 amino acids from the Central region of human DPP10.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDPP10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DPP10
Synonyms DPRP3, KIAA1492
Function Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q6NXK7, ECO:0000269|PubMed:14566338}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P42658}
Tissue Location Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

DPP10 is a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties.

REFERENCES

Blakey J.D., et.al., Thorax 64:381-387(2009).

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