注册 | 登录
点击这里给我发消息
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   Androgen Receptor Antibody   

Androgen Receptor Antibody

Rabbit mAb

     
  • 0 - Androgen Receptor Antibody AP90097
    Western blot analysis of Androgen Receptor expression in (1) T47D cell lysate;(2) LnCaP cell lysate.
  • 0 - Androgen Receptor Antibody AP90097
    Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using Androgen Receptor Antibody.
  • 0 - Androgen Receptor Antibody AP90097
    Immunofluorescent analysis of Lncap cells, using Androgen Receptor Antibody .
  • 产品详情
  • 实验流程
Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, ICC, IP, IHF
Primary Accession P10275
Reactivity Human
Clonality Monoclonal
Other Names SBMA; HYSP1; AIS; TFM; DHTR; NR3C4; HUMARA; SMAX1;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 99188 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP 1:30
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human Androgen Receptor
Description Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding. This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name AR
Synonyms DHTR, NR3C4
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Cellular Location Nucleus. Cytoplasm Note=Detected at the promoter of target genes (PubMed:25091737) Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.
Tissue Location [Isoform 2]: Mainly expressed in heart and skeletal muscle.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

FeedBack

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-88856768 tech-china@abcepta.com.


我要评价