Filamin A antibody
Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IHC, IF, FC, ICC, IHF |
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Primary Accession | P21333 |
Reactivity | Rat, Human, Mouse |
Clonality | Monoclonal |
Other Names | ABP-280; ABPX; actin binding protein 280; Alpha-filamin; filamin 1; filamin A, alpha; FLN1; FLNA; FMD; MNS; NHBP; Non-muscle filamin; OPD; OPD1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 280739 Da |
Dilution | WB 1:1000~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 FC 1:50 |
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Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human Filamin A |
Description | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | FLNA |
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Synonyms | FLN, FLN1 |
Function | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). |
Cellular Location | Cytoplasm, cell cortex. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8BTM8}. Perikaryon {ECO:0000250|UniProtKB:Q8BTM8}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q8BTM8}. Cell projection, podosome {ECO:0000250|UniProtKB:Q8BTM8}. Note=Colocalizes with CPMR1 in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). Localized to the core of myotube podosomes (By similarity). {ECO:0000250|UniProtKB:Q8BTM8} |
Tissue Location | Ubiquitous. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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Cat# AP90203