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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   HIF-1 beta Antibody    

HIF-1 beta Antibody

Rabbit mAb

     
  • 1 - HIF-1 beta Antibody  AP90541
    Western blot analysis of HIF-1 beta expression in Human fetal kidney lysate.
  • 2 - HIF-1 beta Antibody  AP90541
    Immunohistochemical analysis of paraffin-embedded human colon, using HIF-1 beta Antibody .
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P27540
Reactivity Human
Clonality Monoclonal
Other Names ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 86636 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:500~1:2000
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human HIF-1 beta
Description HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name ARNT (HGNC:700)
Synonyms BHLHE2
Function Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'- TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Cellular Location Nucleus.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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