HIF-1 beta Antibody

Rabbit mAb

Western blot analysis of HIF-1 beta expression in Human fetal kidney lysate.
Immunohistochemical analysis of paraffin-embedded human colon, using HIF-1 beta Antibody .

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC
Primary Accession	P27540
Reactivity	Human
Clonality	Monoclonal
Other Names	ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2;
Isotype	Rabbit IgG
Host	Rabbit
Calculated MW	87 KDa

Additional Information
Dilution	WB 1:500~1:2000 IHC 1:500~1:2000
Purification	Affinity-chromatography
Immunogen	A synthesized peptide derived from human HIF-1 beta
Description	HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.
Storage Condition and Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.