癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HMGA1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application 
| IF, WB, FC, E |
|---|---|
| Primary Accession | P17096 |
| Other Accession | Q8K585, P17095, Q9QXP3 |
| Reactivity | Human, Mouse |
| Predicted | Hamster, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11676 Da |
| Antigen Region | 64-93 aa |
| Gene ID | 3159 |
|---|---|
| Other Names | High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein A1, High mobility group protein R, HMGA1, HMGIY |
| Target/Specificity | This HMGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the C-terminal region of human HMGA1. |
| Dilution | WB~~1:1000 IF~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HMGA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGA1 |
|---|---|
| Synonyms | HMGIY |
| Function | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| Cellular Location | Nucleus. Chromosome. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.
REFERENCES
Mu,G., et.al., Hum. Pathol. 41 (4), 493-502 (2010)
Kim,J.J., et.al., J. Hum. Genet. 55 (1), 27-31 (2010)
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