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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   CD79a Antibody   

CD79a Antibody

Rabbit mAb

     
  • 0 - CD79a Antibody AP91502
    Western blot analysis of CD79a expression in human spleen lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, FC, ICC, IHF
Primary Accession P11912
Reactivity Human
Clonality Monoclonal
Other Names B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Surface IgM-associated protein; CD79a; IGA; MB1; CD79A;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 25038 Da
Additional Information
Dilution WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:30
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human CD79a
Description Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases. CD79A is a marker for B-lineage lymphoblastic leukemia; mutations in the corresponding mb-1 gene are responsible for abnormally low levels of functional B cell receptors in some cases of chronic B-cell lymphocytic leukemia.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name CD79A
Synonyms IGA, MB1
Function Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B- cells.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Tissue Location B-cells.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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