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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   FADD Antibody    

FADD Antibody

Rabbit mAb

     
  • 1 - FADD Antibody  AP91555
    Western blot analysis of FADD expression in A431 cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, FC, ICC, IP, IHF
Primary Accession Q13158
Reactivity Human
Clonality Monoclonal
Other Names FADD protein; MORT1;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 23279 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human FADD
Description Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}
Function Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:23955153, PubMed:24025841, PubMed:7538907, PubMed:9184224). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:7538907, PubMed:9184224). Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225, PubMed:24204270).
Cellular Location Cytoplasm.
Tissue Location Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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