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FLAD1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NFF5 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65266 Da |
| Antigen Region | 551-580 aa |
| Gene ID | 80308 |
|---|---|
| Other Names | FAD synthase, FAD pyrophosphorylase, FMN adenylyltransferase, Flavin adenine dinucleotide synthase, Molybdenum cofactor biosynthesis protein-like region, FAD synthase region, FLAD1 |
| Target/Specificity | This FLAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-580 amino acids from the C-terminal region of human FLAD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FLAD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FLAD1 |
|---|---|
| Function | This enzyme has two activities: FAD diphosphatase activity and FAD synthase activity (PubMed:16643857, PubMed:21924249, PubMed:21951714, PubMed:23443125, PubMed:25135855, PubMed:26277395, PubMed:27259049, PubMed:31351152, PubMed:38688286). FAD diphosphatase acts on FAD and NADH to produce FMN and NMNH(2-), respectively (PubMed:26277395, PubMed:31351152, PubMed:38688286). FAD synthase catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (PubMed:16643857, PubMed:21924249, PubMed:21951714, PubMed:23443125, PubMed:27259049, PubMed:38688286). In addition to its catalytic activities, the protein also facilitates the delivery of FAD to client apo-flavoproteins (PubMed:25954742). The balance between FAD synthesis and hydrolysis may be regulated by redox- sensing cysteine residues (PubMed:25135855, PubMed:26277395). At a much lower rate, FAD synthase catalyzes the reverse pyrophosphorolytic reaction (PubMed:21951714, PubMed:23443125, PubMed:25135855, PubMed:26277395). FAD synthase can also convert roseoflavin mononucleotide (RoFMN) to roseoflavin adenine dinucleotide (RoFAD); RoFMN is produced by riboflavin kinase when acting on the antibiotic roseoflavin (RoF) (PubMed:21924249). FAD synthase cannot convert 8- demethyl-8-amino-riboflavin mononucleotide (AFMN) to 8-demethyl-8- amino-riboflavin adenine dinucleotide (AFAD); AFMN is produced by riboflavin kinase when acting on the antibiotic 8-demethyl-8-amino- riboflavin (AF) (PubMed:21924249). |
| Cellular Location | Nucleus. [Isoform 2]: Cytoplasm, cytosol |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FLAD1 encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
REFERENCES
Lin,J., et.al., J. Neurol. 256 (5), 774-782 (2009)
Brizio,C., et.al., Biochem. Biophys. Res. Commun. 344 (3), 1008-1016 (2006)
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Cat# AP9198b
