癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MPP6 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9NZW5 |
| Other Accession | Q9JLB0 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61117 Da |
| Antigen Region | 360-388 aa |
| Gene ID | 51678 |
|---|---|
| Other Names | MAGUK p55 subfamily member 6, Veli-associated MAGUK 1, VAM-1, MPP6, VAM1 |
| Target/Specificity | This MPP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human MPP6. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPP6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PALS2 (HGNC:18167) |
|---|---|
| Synonyms | MPP6, VAM1 |
| Cellular Location | Membrane; Peripheral membrane protein |
| Tissue Location | Abundant in testis, brain, and kidney with lower levels detectable in other tissues |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily.
REFERENCES
Scheel,A.K., et.al., Ann. Rheum. Dis. 65 (5), 595-600 (2006)
Rush,J., et.al., Nat. Biotechnol. 23 (1), 94-101 (2005)
Rush,J., et.al., Nat. Biotechnol. 23 (1), 94-101 (2005)
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