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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   KDM4B / JMJD2B Antibody   

KDM4B / JMJD2B Antibody

Rabbit mAb

     
  • 1 - KDM4B / JMJD2B Antibody AP92348
    Western blot analysis of KDM4B / JMJD2B expression in (1) SW480 cell lysate; (2) Mouse testis cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, FC, ICC, IHF
Primary Accession O94953
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Other Names JHDM3B; JMJD2B; Kdm4b; TDRD14B;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 121897 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:200
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human KDM4B / JMJD2B
Description Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name KDM4B
Synonyms JHDM3B, JMJD2B, KIAA0876
Function Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys- 20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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