HIRA Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IF, FC, ICC, IP |
---|---|
Primary Accession | P54198 |
Reactivity | Human |
Clonality | Monoclonal |
Other Names | DGCR1; HIR; HIRA; TUP 1; TUPLE1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 111835 Da |
Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:100 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human HIRA |
Description | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | HIRA |
---|---|
Synonyms | DGCR1, HIR, TUPLE1 |
Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
Cellular Location | Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence |
Tissue Location | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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