癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLCB1 Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9NQ66 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Other Names | 1 phosphatidylinositol 4, 5 bisphosphate phosphodiesterase beta 1; 1-phosphatidylinositol 4; EIEE12; Inositoltrisphosphohydrolase; Monophosphatidylinositol phosphodiesterase; Phosphb; Phosphoinositidase C ; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta 1; Phospholipase C beta 1 (phosphoinositide-specific); Phospholipase C I; Phospholipase C-beta-1; Phospholipase C-I; PI PLC; PLC 1; PLC beta 1; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; Plcb1; PLCbeta1; Triphosphoinositide phosphodiesterase; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 138567 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human PLCB1 |
| Description | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | PLCB1 (HGNC:15917) |
|---|---|
| Synonyms | KIAA0581 |
| Function | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5- bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein- coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. |
| Cellular Location | Nucleus membrane {ECO:0000250|UniProtKB:Q9Z1B3}. Cytoplasm {ECO:0000250|UniProtKB:P10687}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:Q9Z1B3} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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