癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOCS7 Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | O14512 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Other Names | Ash and phospholipase C gamma-binding protein; NAP4; Nck; Nck Ash and phospholipase C binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS4; SOCS6; Socs7; Suppressor of cytokine signaling 7; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 62969 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human SOCS7 |
| Description | Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | SOCS7 {ECO:0000303|PubMed:16127460, ECO:0000312|HGNC:HGNC:29846} |
|---|---|
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (PubMed:16127460). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (By similarity). The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development (By similarity). Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation (PubMed:16127460). Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA (PubMed:15677474). |
| Cellular Location | Cytoplasm. Nucleus Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus (PubMed:17803907). Rapidly relocalizes to the nucleus after UV irradiation (PubMed:17803907) Cytoplasmic location depends upon SEPT7 presence (PubMed:17803907) |
| Tissue Location | Expressed in brain and leukocytes (PubMed:9344857). Also in fetal lung fibroblasts and fetal brain (PubMed:9344857) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
