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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)   

phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)

Rabbit mAb

     
  • 1 - phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) AP93209
    Western blot analysis of phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) expression in Jurkat treated with Pervanadate lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P19174
Reactivity Human
Clonality Monoclonal
Other Names PLC-148; PLC-II; PLC-gamma1; PLC1; PLCG-1; Phospholipase C-gamma-1;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 148532 Da
Additional Information
Dilution WB 1:500~1:2000
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)
Description Plays a role in actin reorganization and cell migration. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name PLCG1 (HGNC:9065)
Synonyms PLC1
Function Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity).
Cellular Location Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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