癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FABP5 Rabbit pAb
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Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | Q01469 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Immunogen | Recombinant protein of human FABP5 (NP_001435.1). |
| Purification | Affinity Purified |
| Calculated MW | 15164 Da |
| Gene ID | 2171 |
|---|---|
| Other Names | EFABP; KFABP; E-FABP; PAFABP; PA-FABP |
| Dilution | WB~~1:1000 IHC-P~~1:50~200 IF~~1:50~200 ICC~~N/A |
| Format | Liquid in PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FABP5 (HGNC:3560) |
|---|---|
| Function | Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:21395585, PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987). |
| Cellular Location | Cytoplasm. Nucleus Synapse {ECO:0000250|UniProtKB:Q05816}. Postsynaptic density {ECO:0000250|UniProtKB:Q05816}. Secreted {ECO:0000250|UniProtKB:Q05816}. Note=Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity). {ECO:0000250|UniProtKB:Q05816, ECO:0000269|PubMed:24692551} |
| Tissue Location | Keratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585) |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind.
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