癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MOTS-C Rabbit Polyclonal Antibody
MOTS-C Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC |
|---|---|
| Primary Accession | A0A0C5B5G6 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Calculated MW | 2175 Da |
| Other Names | Mitochondrial-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1 (HGNC:7470) |
|---|---|
| Dilution | IHC~~1:100~500 |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MT-RNR1 (HGNC:7470) |
|---|---|
| Function | Regulates insulin sensitivity and metabolic homeostasis (PubMed:25738459, PubMed:33468709). Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4- carboxamide (AICAR) and the activation of the metabolic regulator 5'- AMP-activated protein kinase (AMPK) (PubMed:25738459). Protects against age-dependent and diet-induced insulin resistance as well as diet- induced obesity (PubMed:25738459). In response to metabolic stress, translocates to the nucleus where it binds to antioxidant response elements (ARE) present in the promoter regions of a number of genes and plays a role in regulating nuclear gene expression in an NFE2L2- dependent manner and increasing cellular resistance to metabolic stress (PubMed:29983246). Increases mitochondrial respiration and levels of CPT1A and cytokines IL1B, IL6, IL8, IL10 and TNF in senescent cells (PubMed:29886458). Increases activity of the serine/threonine protein kinase complex mTORC2 and reduces activity of the PTEN phosphatase, thus promoting phosphorylation of AKT (PubMed:33554779). This promotes AKT-mediated phosphorylation of transcription factor FOXO1 which reduces FOXO1 activity, leading to reduced levels of MSTN and promotion of skeletal muscle growth (PubMed:33554779). Promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the TGFB/SMAD pathway (PubMed:30468456). Promotes osteoblast proliferation and osteoblast synthesis of type I collagens COL1A1 and COL1A2 via the TGFB/SMAD pathway (PubMed:31081069). |
| Cellular Location | Secreted. Mitochondrion. Nucleus Note=Translocates to the nucleus in response to metabolic stress in an AMPK-dependent manner. |
| Tissue Location | Detected in plasma (at protein level) (PubMed:25738459, PubMed:32182209). Also expressed in skeletal muscle (at protein level) (PubMed:32182209). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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