癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GSDMD (4O13) Rabbit Monoclonal Antibody
GSDMD (4O13) Rabbit Monoclonal Antibody
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- 背景知识
Application 
| WB, IHC-P, FC, IP, IF |
|---|---|
| Primary Accession | Q9D8T2 |
| Reactivity | Mouse, Rat |
| Clonality | Monoclonal |
| Calculated MW | 53238 Da |
| Gene ID | 69146 |
|---|---|
| Other Names | Gasdermin-D, Gasdermin domain-containing protein 1, Gasdermin-D, N-terminal, GSDMD-NT, mGSDMD-NTD, p30, Gasdermin-D, C-terminal, GSDMD-CT, mGSDMD-CTD, p20, Gasdermin-D, p13, Gasdermin-D, 13 kDa, 13 kDa GSDMD, Gasdermin-D, p40, Gsdmd {ECO:0000303|PubMed:26611636, ECO:0000312|MGI:MGI:1916396} |
| Dilution | WB~~1:1000 IHC-P~~1:50~200 FC~~1:10~50 IP~~N/A IF~~1:50~200 |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Gsdmd {ECO:0000303|PubMed:26611636, ECO:0000312|MGI:MGI:1916396} |
|---|---|
| Function | [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:26611636, PubMed:27383986, PubMed:27385778, PubMed:27418190). |
| Cellular Location | [Gasdermin-D]: Cytoplasm, cytosol Inflammasome. Note=In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor. [Gasdermin-D, N-terminal]: Cytoplasm, cytosol. Note=(Microbial infection) Upon infection by M.tuberculosis, localization to cell membrane is prevented by M.tuberculosis phosphatase PtpB that catalyzes dephosphorylation of phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol 4- phosphate, thereby inhibiting the membrane targeting of Gasdermin-D, N- terminal and subsequent cytokine release and pyroptosis [Gasdermin-D, C-terminal]: Cytoplasm, cytosol |
| Tissue Location | Highly expressed in brain endothelial cells. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]
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