癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SMNDC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, FC, E |
|---|---|
| Primary Accession | O75940 |
| Other Accession | Q4QQU6, Q8BGT7, Q3T045 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26711 Da |
| Antigen Region | 11-41 aa |
| Gene ID | 10285 |
|---|---|
| Other Names | Survival of motor neuron-related-splicing factor 30, 30 kDa splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1, SMNDC1, SMNR, SPF30 |
| Target/Specificity | This SMNDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human SMNDC1. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SMNDC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMNDC1 |
|---|---|
| Synonyms | SMNR, SPF30 |
| Function | Involved in spliceosome assembly. |
| Cellular Location | Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies |
| Tissue Location | Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This protein is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This protein is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.
REFERENCES
Little,J.T. J. Biol. Chem. 283 (13), 8145-8152 (2008)
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)
Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)
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