癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UCP1 (8C9) Rabbit Monoclonal Antibody
UCP1 (8C9) Rabbit Monoclonal Antibody
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, IP, IF |
|---|---|
| Primary Accession | P12242, P04633 |
| Reactivity | Mouse, Rat |
| Clonality | Monoclonal |
| Calculated MW | 33248 Da |
| Gene ID | 22227 |
|---|---|
| Dilution | WB~~1:1000 IHC-P~~1:50~200 IP~~N/A IF~~1:50~200 |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ucp1 {ECO:0000312|MGI:MGI:98894} |
|---|---|
| Function | Mitochondrial transporter that functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP (PubMed:23063128). Responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (PubMed:19187776, PubMed:23063128, PubMed:27027295, PubMed:9139827). Regulates the production of reactive oxygen species/ROS by mitochondria (PubMed:20416274, PubMed:20466728). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04633} |
| Tissue Location | Expressed in brown adipose tissue. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Enables long-chain fatty acid binding activity; oxidative phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including cellular response to cold; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation and regulation of transcription by RNA polymerase II. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; adrenal gland; submandibular gland; testis; and thymus. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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