癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
USP16 (18S13) Rabbit Monoclonal Antibody
USP16 (18S13) Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q99LG0, Q2KJ09 |
| Reactivity | Mouse, Rat |
| Clonality | Monoclonal |
| Calculated MW | 93434 Da |
| Gene ID | 74112 |
|---|---|
| Dilution | WB~~1:1000 |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Usp16 |
|---|---|
| Function | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:24034696). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser- 11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:24034696). In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit. Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability (PubMed:36206347). |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03062}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03062} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Predicted to enable several functions, including cysteine-type peptidase activity; ubiquitin binding activity; and zinc ion binding activity. Involved in monoubiquitinated histone H2A deubiquitination and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human USP16 (ubiquitin specific peptidase 16). [provided by Alliance of Genome Resources, Apr 2022]
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