癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Frzb (10J17) Rabbit Monoclonal Antibody
Frzb (10J17) Rabbit Monoclonal Antibody
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- 背景知识
Application 
| WB, ICC, FC, IP |
|---|---|
| Primary Accession | P97401 |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 36011 Da |
| Gene ID | 20378 |
|---|---|
| Other Names | Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, Frzb, Fiz, Fre, Frzb1, Sfrp3 |
| Dilution | WB~~1:1000 ICC~~N/A FC~~1:10~50 IP~~N/A |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Frzb |
|---|---|
| Synonyms | Fiz, Fre, Frzb1, Sfrp3 |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in kidney, brain, testis. Weak expression in spleen and heart. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Apr 2022]
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