癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
uPA Receptor/U-PAR (1F11) Rabbit Monoclonal Antibody
uPA Receptor/U-PAR (1F11) Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, IP |
|---|---|
| Primary Accession | P35456 |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 35428 Da |
| Gene ID | 18793 |
|---|---|
| Other Names | Urokinase plasminogen activator surface receptor, U-PAR, uPAR, CD87, Plaur |
| Dilution | WB~~1:1000 FC~~1:10~50 IP~~N/A |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Plaur {ECO:0000312|MGI:MGI:97612} |
|---|---|
| Function | GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling. |
| Cellular Location | [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q03405}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q03405}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:Q03405}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q03405}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner {ECO:0000250|UniProtKB:Q03405} |
| Tissue Location | Expressed in angiogenic endothelial cells (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Acts as a receptor for urokinase plasminogen activator
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