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Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) (4Y15) Rabbit Monoclonal Antibody
Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) (4Y15) Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q7L7X3, Q9H2K8, Q9HC79, Q9UL54 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Calculated MW | 116070 Da |
| Gene ID | 57551 |
|---|---|
| Dilution | WB~~1:1000 |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TAOK1 |
|---|---|
| Synonyms | KIAA1361, MAP3K16, MARKK |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G protein-coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
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