癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Tmem27 (14D16) Rabbit Monoclonal Antibody
Tmem27 (14D16) Rabbit Monoclonal Antibody
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- 背景知识
Application 
| WB, IHC-P, ICC, FC, IF |
|---|---|
| Primary Accession | Q9HBJ8 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Calculated MW | 25235 Da |
| Gene ID | 57393 |
|---|---|
| Other Names | Collectrin, Transmembrane protein 27, CLTRN (HGNC:29437) |
| Dilution | WB~~1:1000 IHC-P~~1:50~200 ICC~~N/A FC~~1:10~50 IF~~1:50~200 |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CLTRN (HGNC:29437) |
|---|---|
| Function | Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (PubMed:16330323). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney (By similarity). Colocalizes with SLC6A19 in the early proximal S1 tubule (By similarity). {ECO:0000250|UniProtKB:Q9ESG4} |
| Tissue Location | Kidney; collecting ducts. Pancreas; beta cells of islets. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
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