癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL31 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | Q6EBC2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18205 Da |
| Antigen Region | 13-40 aa |
| Gene ID | 386653 |
|---|---|
| Other Names | Interleukin-31, IL-31, IL31 |
| Target/Specificity | This IL31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human IL31. |
| Dilution | IHC-P~~1:100~500 FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IL31 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IL31 (HGNC:19372) |
|---|---|
| Function | Functions as a cytokine that binds to IL31RA, a membrane- bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) (PubMed:15184896, PubMed:15627637). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding to IL31RA, induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR (PubMed:15627637). These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (PubMed:15184896, PubMed:15627637). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15627637). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma.
REFERENCES
Le Saux, S., et al. J. Biol. Chem. 285(5):3470-3477(2010) Zucchelli, M., et al. Inflamm. Bowel Dis. 15(7):961-962(2009) Gutzmer, R., et al. J. Allergy Clin. Immunol. 123(3):619-625(2009) Zhang, Q., et al. Cytokine Growth Factor Rev. 19 (5-6), 347-356 (2008) : Werfel, T., et al. Chem Immunol Allergy 94, 101-111 (2008) :
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