癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Semaphorin 5B Rabbit pAb
Semaphorin 5B Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9P283 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Dog, Human, Rabbit, Chicken, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 125913 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Semaphorin 5B |
| Epitope Specificity | 201-300/1155 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Single-pass type III membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA5B (semaphorin-5B), also known as SEMAG, is a 1151 amino acid member of the semaphorin family. Localized to the membrane, SEMA5B is a single-pass type III protein that functions to convey positive axonal guidance cues and can induce calpain-mediated cleavage of calcineurin. Three isoforms exist due to alternative splicing events. |
| Gene ID | 54437 |
|---|---|
| Other Names | Semaphorin-5B, SEMA5B, KIAA1445, SEMAG |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEMA5B |
|---|---|
| Synonyms | KIAA1445, SEMAG |
| Function | May act as a positive axonal guidance cue. |
| Cellular Location | Membrane; Single-pass type III membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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