癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STRA6 Antibody (C-term)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BX79 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Gene ID | 64220 |
|---|---|
| Other Names | Stimulated by retinoic acid gene 6 protein homolog, STRA6 |
| Target/Specificity | This STRA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-614 amino acids from the C-terminal region of human STRA6. |
| Dilution | WB~~1:1000 IHC-P~~1:100~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STRA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STRA6 |
|---|---|
| Function | Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031). |
| Cellular Location | Cell membrane; Multi- pass membrane protein. Note=In the retinal pigment epithelium localizes to the basolateral membrane {ECO:0000250|UniProtKB:Q0V8E7} |
| Tissue Location | Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris |
|
Author : Chen CH1, Ke LY1, Chan HC1, Lee AS2, Lin KD1, Chu CS1, Lee MY1, Hsiao PJ1, Hsu C1, Chen CH3, Shin SJ4. J Lipid Res. 2016 Jun 2. pii: jlr.M067215. [Epub ahead of print] |
27256691 |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
STRA6 is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9).
REFERENCES
Chassaing, N., et al. Hum. Mutat. 30 (5), E673-E681 (2009)
West, B., et al. Am. J. Med. Genet. A 149A (3), 539-542 (2009)
Kawaguchi, R., et al. J. Biol. Chem. 283(22):15160-15168(2008)
Isken, A., et al. Cell Metab. 7(3):258-268(2008)
White, T., et al. Mol. Vis. 14, 2458-2465 (2008)
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