癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Recombinant Anti-SLFN12 Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q8IYM2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Calculated MW | 66972 Da |
| Gene ID | 55106 |
|---|---|
| Other Names | Schlafen family member 12 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within human SLFN12 protein. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) FC~~1:10~50 |
| Format | Liquid in PBS, pH 7.3, 50% glycerol, 0.05% BSA, and 0.05% Proclin300. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLFN12 (HGNC:25500) |
|---|---|
| Function | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34272366, PubMed:34707099, PubMed:35104454). May play a role in cell differentiation (PubMed:30045019). |
| Cellular Location | Nucleus. Cytoplasm, cytosol |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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