Anti-Hepsin Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, IF/IC
Primary Accession	P05981
Reactivity	Human
Host	Mouse
Clonality	Monoclonal (clone: 2D5)
Calculated MW	45011 Da

Additional Information
Gene ID	3249
Other Names	TMPRSS1; Serine protease hepsin; Transmembrane protease serine 1
Target/Specificity	Recombinant fusion protein of human HPN
Dilution	FC~~1:10~50 IF/IC~~N/A
Format	Mouse IgG2a kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	HPN
Synonyms	TMPRSS1
Function	Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). Plays a role in cell growth and maintenance of cell morphology (PubMed:21875933, PubMed:8346233). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Cellular Location	Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein
Tissue Location	Detected in liver and kidney.