Anti-CD226 Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, IF/IC
Primary Accession	Q15762
Reactivity	Human
Host	Mouse
Clonality	Monoclonal (clone: TX25)
Calculated MW	38614 Da

Additional Information
Gene ID	10666
Other Names	DNAM1; CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD226
Target/Specificity	Native purified human CD226
Dilution	FC~~1:10~50 IF/IC~~N/A
Format	Mouse IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	CD226
Synonyms	DNAM1
Function	Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus- infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity).
Cellular Location	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.
Tissue Location	Expressed by peripheral blood T-lymphocytes.