Anti-CD273 Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	FC, IF/IC
Primary Accession	Q9BQ51
Reactivity	Human
Host	Mouse
Clonality	Monoclonal (clone: 3.2)
Calculated MW	30957 Da

Additional Information
Gene ID	80380
Other Names	B7DC; CD273; PDCD1L2; PDL2; Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; CD273
Target/Specificity	Human B7-DC transfected cells
Dilution	FC~~1:10~50 IF/IC~~N/A
Format	Mouse IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	PDCD1LG2
Synonyms	B7DC, CD273, PDCD1L2, PDL2
Function	Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527).
Cellular Location	[Isoform 3]: Secreted [Isoform 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location	Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus