癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLPTM1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96KA5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62229 Da |
| Antigen Region | 509-538 aa |
| Gene ID | 81037 |
|---|---|
| Other Names | Cleft lip and palate transmembrane protein 1-like protein, CLPTM1-like protein, Cisplatin resistance-related protein 9, CRR9p, CLPTM1L, CRR9 |
| Target/Specificity | This CLPTM1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-538 amino acids from the C-terminal region of human CLPTM1L. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLPTM1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLPTM1L |
|---|---|
| Synonyms | CRR9 |
| Function | Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn- glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) (PubMed:35344438). GPI is a lipid glycoconjugate involved in post-translational modification of proteins (PubMed:35344438). Can also translocate 1,2-diacyl-sn-glycero-3- phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N- acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro (PubMed:35344438). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CLPTM1L enhances cisplatin-mediated apoptosis, when overexpressed.
REFERENCES
?Petersen, G.M., et al. Nat. Genet. 42(3):224-228(2010)
?Wang, Y., et al. Carcinogenesis 31(2):234-238(2010)
?Landi, M.T., et al. Am. J. Hum. Genet. 85(5):679-691(2009)
?Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
?Broderick, P., et al. Cancer Res. 69(16):6633-6641(2009)
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