癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Periplakin Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O60437 |
| Other Accession | O60437 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 204747 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Periplakin |
| Epitope Specificity | 1-100/1756 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the plakin or cytolinker family. Contains 2 plectin repeats. Contains 4 spectrin repeats. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008] |
| Gene ID | 5493 |
|---|---|
| Other Names | PEPL_HUMAN; PPL; 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; KIAA0568; PEPL_MOUSE; periplakin |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPL |
|---|---|
| Synonyms | KIAA0568 |
| Function | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. |
| Cellular Location | Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250|UniProtKB:Q9R269}. Lateral cell membrane {ECO:0000250|UniProtKB:Q9R269}. Cytoplasm {ECO:0000250|UniProtKB:Q9R269} |
| Tissue Location | Expressed in stratified squamous epithelia and in some other epithelia. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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