癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FAM64A Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9BSJ6 |
| Other Accession | Q9BSJ6 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27480 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RCS1/FAM64A |
| Epitope Specificity | 151-248/248 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus |
| SUBUNIT | Isoform 1 and isoform 2 interact with PICALM; this interaction may target PICALM to the nucleus (PubMed:16491119). During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase (PubMed:18757745). |
| Post-translational modifications | Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PIMREG (PICALM Interacting Mitotic Regulator) is a Protein Coding gene. Diseases associated with PIMREG include Suppurative Periapical Periodontitis. |
| Gene ID | 54478 |
|---|---|
| Other Names | CATS; FAM64A; RCS1; PIMRE_HUMAN; PIMREG; CALM-interactor expressed in thymus and spleen; PICALM-interacting mitotic regulator; Regulator of chromosome segregation protein 1; PICALM interacting mitotic regulator; family with sequence similarity 64, member A; family with sequence similarity 64 member A; CALM interacting protein expressed in thymus and spleen |
| Target/Specificity | Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PIMREG (HGNC:25483) |
|---|---|
| Function | During mitosis, may play a role in the control of metaphase- to-anaphase transition. |
| Cellular Location | Nucleus. Nucleus, nucleolus. Note=Partially localizes to the nucleolus. |
| Tissue Location | Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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